Congratulations to Anita Iyer, PhD, postdoctoral fellow in our lab, who has been selected to receive an ASTMH (American Society of Tropical Medicine and Hygiene) Annual Meeting Award, supported in part by the Bill & Melinda Gates Foundation. She will receive funding to attend the conference, held November 13-17 in Atlanta, to present her research on immune responses to oral cholera vaccine in internally displaced persons in South Sudan.
Congratulations to our Undergraduate Research Opportunities Program (UROP) recipients for their poster presentations at recent research conferences! Joe Fuell presented a poster on “Immune Response to Native American Antidiarrheals” at the Utah Conference on Undergraduate Research in February (left photo), and Amanda Barrett presented a poster on “Use of Stool Immune Transcriptome to Predict Recurrent Clostridium difficile Infection” at the University of Utah Undergraduate Symposium last week (right photo).
The Leung lab has been awarded a grant from the University of Utah’s Center for Clinical and Translational Science and Program in Personalized Health to identify biomarkers for refractory Clostridium difficile infection.
Clostridium difficile infection (CDI) is the most common hospital-associated infection, responsible for an estimated 14,000 deaths a year in the US. While there are established antibiotic treatment regimens for CDI, up to 25% of treated cases relapse or recur. In collaboration with investigators from ARUP Laboratories and Intermountain Healthcare, we will be using cutting-edge genomic techniques to identify those who are at risk of developing recurrence of disease.
Announcement and details of other recipients here: http://healthcare.utah.edu/publicaffairs/news/2015/06/06-30-15_Precision_Medicine_Grants_Announcement.php
Congratulations to our 3 University of Utah Undergraduate Research Opportunities Program (UROP) grantees! Amanda, Joe, and Mait all received summer stipends to work on their research projects in our lab.
| Amanda Barrett
The purpose of my UROP project is to determine if there are transcriptomic predictors for patients with recurrent Clostridium difficile infection (CDI). From stool samples, we will isolate host mRNA and analyze gene expression using RNA sequencing and qPCR. Both types of analysis should aid in comparing genes of interest and compare results between patients with recurring CDI, cured CDI, and a control group.
Hundreds of years before the arrival of Western Medicine to the Salt Lake valley Native American tribes used local herbs to treat digestive problems such as diarrhea, stomach pains, and other intestinal problems. My project consists of testing various roots and seeds used by Native Americans such as Rosa Woodsi, Grindelia Squarossa, Rumex crispus and Rhus trilobata. These compounds are being tested for toxicity and activity on human intestinal and immune cells.
The purpose of my UROP project is to study the activation of mucosal-associated invariant T (MAIT) cells. It is already known that some riboflavin metabolites activate MAIT cells. I will test to see if molecules produced by other types of disease-causing bacteria activate MAIT cells in a similar way. The overall goal is to get a better understanding of how diarrhea-causing bacteria affect our immune system.